SR11237

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Chemical Structure| 146670-40-8 同义名 : BMS-649
CAS号 : 146670-40-8
货号 : A1209343
分子式 : C24H28O4
纯度 : 99%+
分子量 : 380.48
MDL号 : MFCD00864137
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(10.51 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 SR11237, also known as BMS-649, is a potent, selective retinoid X receptor (RXR) agonist with no RAR activity. SR11237 results in the formation of RXR/RXR homodimers and transactivation of reporter genes containing RXR response elements[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.63mL

0.53mL

0.26mL

13.14mL

2.63mL

1.31mL

26.28mL

5.26mL

2.63mL
参考文献

[1]Gendimenico GJ, et al. A pleiotropic response is induced in F9 embryonal carcinoma cells and rhino mouse skin by All-trans-retinoic acid, a RAR agonist but not by SR11237, a RXR-selective agonist. J Invest Dermatol. 1994;102(5):676-680.

[2]Dupuis H, et al. Exposure to the RXR Agonist SR11237 in Early Life Causes Disturbed Skeletal Morphogenesis in a Rat Model. Int J Mol Sci. 2019;20(20):5198. Published 2019 Oct 20.

[3]H.L. Dupuis. The RXR agonist SR-11237 affects skeletal development. ABSTRACT ONLY

[4] VOLUME 24, SUPPLEMENT 1, S147, APRIL 01, 2016.