Pulrodemstat benzenesulfonate

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Chemical Structure| 2097523-60-7 同义名 : CC-90011 benzenesulfonate; LSD1-IN-7 benzenesulfonate; Pulrodemstat besylate
CAS号 : 2097523-60-7
货号 : A1207394
分子式 : C30H29F2N5O5S
纯度 : 99%+
分子量 : 609.64
MDL号 : MFCD32644589
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(82.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • KDM1
描述 CC-90011 benzenesulfonate acts as a potent, selective, reversible, and orally active lysine specific demethylase-1 (LSD1) inhibitor with an IC50 of 0.25 nM. It exhibits minimal enzymatic inhibition towards LSD2, MAO-A, and MAO-B. CC-90011 benzenesulfonate promotes differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells, demonstrating significant anticancer efficacy [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.64mL

0.33mL

0.16mL

8.20mL

1.64mL

0.82mL

16.40mL

3.28mL

1.64mL
参考文献

[1]Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529.