p-Toluic acid

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Chemical Structure| 99-94-5 同义名 : 对甲基苯甲酸 ;4-Methylbenzoic acid
CAS号 : 99-94-5
货号 : A120071
分子式 : C8H8O2
纯度 : 98%
分子量 : 136.15
MDL号 : MFCD00002565
存储条件:

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(771.22 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

生物活性
描述 p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid, used in the synthesis of various intermediates such as p-aminomethylbenzoic acid (PAMBA) and p-toluonitrile. Research has indicated that p-Toluic acid may have potential reproductive toxicity. Repeated administration of doses at 1 g/kg has been shown to produce various adverse effects on the epididymis[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.34mL

1.47mL

0.73mL

36.72mL

7.34mL

3.67mL

73.45mL

14.69mL

7.34mL

参考文献

[1]Pfennig T, et al. The formation of p-toluic acid from coumalic acid: a reaction network analysis[J]. Green Chemistry, 2017, 19(14): 3263-3271.

[2]Shirota M, et al. Screening of toxicological properties of 4-methylbenzoic acid by oral administration to rats. J Toxicol Sci. 2008 Oct;33(4):431-45.