PF429242 2HCl

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Chemical Structure| 2248666-66-0 同义名 : PF-429242 (hydrochloride); PF429242 dihydrochloride
CAS号 : 2248666-66-0
货号 : A1196083
分子式 : C25H37Cl2N3O2
纯度 : 99%+
分子量 : 482.49
MDL号 : MFCD22683795
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(176.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(103.63 mM)，配合低频超声助溶
生物活性
描述 PF429242 dihydrochloride is a reversible and competitive inhibitor of SREBP site 1 protease (S1P) with an IC50 of 175 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.07mL

0.41mL

0.21mL

10.36mL

2.07mL

1.04mL

20.73mL

4.15mL

2.07mL
参考文献

[1]Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol

[2]Uchida L, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016 Feb 10;8(2). pii: E46. doi: 10.3390/v8020046.

[3]Urata S, et al. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011 Jan;85(2):795-803.