NSP-805

产品说明书

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Chemical Structure| 125068-54-4 同义名 : -
CAS号 : 125068-54-4
货号 : A1177318
分子式 : C17H19N3O2
纯度 : 99%+
分子量 : 297.35
MDL号 : -
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(134.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 In isolated guinea pig left atria, NSP-805 exhibits a positive inotropic EC50 value with a potency order of 0.18 μM. The in vitro positive inotropic effects of NSP-805 are accompanied by increases in tissue cyclic AMP and are abolished by carbachol[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.36mL

0.67mL

0.34mL

16.82mL

3.36mL

1.68mL

33.63mL

6.73mL

3.36mL
参考文献

[1]Mochizuki N, et al. Cardiovascular effects of NSP-804 and NSP-805, novel cardiotonic agents with vasodilator properties. J Cardiovasc Pharmacol. 1993 Jun;21(6):983-95.

[2]Uchida H, et al. [The effect of phosphodiesterase type 3 inhibitor on chorio-retinal blood flow in rabbits eyes]. Nippon Ganka Gakkai Zasshi. 2002 Oct;106(10):615-20.