CK-666

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Chemical Structure| 442633-00-3 同义名 : -
CAS号 : 442633-00-3
货号 : A1177290
分子式 : C18H17FN2O
纯度 : 99%+
分子量 : 296.34
MDL号 : MFCD03036271
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(404.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 CK-666 is a potent inhibitor of the Arp2/3 complex, an actin-related protein, displaying an IC50 value of 12 μM. By binding to the Arp2/3 complex, CK-666 stabilizes its inactive form and prevents the movement of Arp2 and Arp3 subunits into an activated, filament-like conformation[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.37mL

0.67mL

0.34mL

16.87mL

3.37mL

1.69mL

33.75mL

6.75mL

3.37mL
参考文献

[1]Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.

[2]Brieuc P Perot, et al. Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4+ T Lymphocytes. Front Cell Infect Microbiol. 2020 Feb 28;10:70.