CD38 inhibitor 1

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Chemical Structure| 1700637-55-3 同义名 : CD38-IN-78c; compound 78c; CD38 Inhibitor 78c; MDK-7553
CAS号 : 1700637-55-3
货号 : A1177137
分子式 : C22H27N3O3S
纯度 : 99%+
分子量 : 413.53
MDL号 : MFCD32062812
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(60.45 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 CD38 inhibitor 1 is a highly potent inhibitor of CD38, with IC50s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38, respectively [1].
作用机制 CD38 inhibitor 1 binds to catalytically active sites of the target[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.42mL

0.48mL

0.24mL

12.09mL

2.42mL

1.21mL

24.18mL

4.84mL

2.42mL
参考文献

[1]Haffner CD, et al. Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem. 2015 Apr 23;58(8):3548-71.