FLT3-IN-3

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Chemical Structure| 2229050-90-0 同义名 : SAN50900
CAS号 : 2229050-90-0
货号 : A1176818
分子式 : C27H38N8O
纯度 : 95%
分子量 : 490.64
MDL号 : MFCD31813658
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(509.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 FLT3-IN-3 is very effective in inhibiting the proliferation of FLT3-ITD-positive MV4-11 and MOLM-13 cell lines at low nanomolar concentrations (GI50 values of 2 nM and 1 nM, respectively). At a concentration of less than 100 nM for 1 h, FLT3-IN-3 abolished the phosphorylation of STAT5 at the Y694 site, which is a key component of STAT5 phosphorylation. FLT3-IN-3 also reduced the phosphorylation of ERK1/2 (T202/Y204) and MEK1/2 (S217/221) in the MAPK cascade. FLT3-IN-3 also interfered with the PI3K/AKT pathway and reduced the phosphorylation of the AKT S473 site[ 1]. 1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.04mL

0.41mL

0.20mL

10.19mL

2.04mL

1.02mL

20.38mL

4.08mL

2.04mL
参考文献

[1]Gucký T, et al. Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations. J Med Chem. 2018 May 10;61(9):3855-3869.