Elexacaftor
产品说明书
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同义名 : | VX-445 |
| CAS号 : | 2216712-66-0 | |
| 货号 : | A1176769 | |
| 分子式 : | C26H34F3N7O4S | |
| 纯度 : | 99%+ | |
| 分子量 : | 597.65 | |
| MDL号 : | MFCD32067875 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 120 mg/mL(200.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Elexacaftor is a modulator of CFT that promotes CFTR processing and trafficking, thereby increasing the amount of CFTR on the cell surface[1].Elexacaftor is a new generation CFTR modifier designed to restore the function of the Phe508del CFTR protein. Elexacaftor has potential for the treatment of cystic fibrosis[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.67mL 0.33mL 0.17mL |
8.37mL 1.67mL 0.84mL |
16.73mL 3.35mL 1.67mL |
| 参考文献 |
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