CH7057288
产品说明书
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同义名 : | - |
| CAS号 : | 2095616-82-1 | |
| 货号 : | A1176610 | |
| 分子式 : | C32H31N3O5S | |
| 纯度 : | 98% | |
| 分子量 : | 569.67 | |
| MDL号 : | MFCD31715415 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(61.44 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | CH7057288 is a potent and selective TRK inhibitor. In an intracranial implantation model simulating brain metastases, CH7057288 induced intracranial tumour regression and greatly improved event-free survival. CH7057288 can be used as a therapeutic agent for TRK fusion-positive cancers. The TRK receptor tyrosine kinase is expressed in a variety of cancer types, including lung and colorectal cancers, in the form of fusion proteins encoded by various fusion genes[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.76mL 0.35mL 0.18mL |
8.78mL 1.76mL 0.88mL |
17.55mL 3.51mL 1.76mL |
| 参考文献 |
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