TAS4464 HCl

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Chemical Structure| 1848959-11-4 同义名 : TAS4464 hydrochloride
CAS号 : 1848959-11-4
货号 : A1175748
分子式 : C21H24ClFN6O6S
纯度 : 99%+
分子量 : 542.97
MDL号 : MFCD32067968
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(193.38 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 5 mg/mL(9.21 mM)，配合低频超声，并水浴加热至45℃助溶
生物活性
描述 TAS4464 (hydrochloride) is a highly potent and selective inhibitor of the NEDD8 activating enzyme (NAE), demonstrating an IC50 value of 0.955 nM[1]. TAS4464 (hydrochloride) is a click chemistry reagent containing an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing azide groups.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.84mL

0.37mL

0.18mL

9.21mL

1.84mL

0.92mL

18.42mL

3.68mL

1.84mL
参考文献

[1]Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.