Mizagliflozin

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Chemical Structure| 666843-10-3 同义名 : DSP-3235 free base; KGA-3235 free base; GSK-1614235; KGA-3235; DSP 3235; DSP-3235, DSP3235; KWA 0711; GSK-1614235 free base
CAS号 : 666843-10-3
货号 : A1167800
分子式 : C28H44N4O8
纯度 : 99%
分子量 : 564.67
MDL号 : MFCD30533437
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(185.95 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(177.09 mM)
生物活性
描述 Mizagliflozin (DSP-3235 free base) is a potent, orally active inhibitor specifically targeting the SGLT1 transporter, with a Ki of 27 nM for human SGLT1, showcasing a 303-fold selectivity over SGLT2. This selectivity positions Mizagliflozin as a promising antidiabetic agent capable of modifying postprandial blood glucose levels. Additionally, it has shown potential in alleviating symptoms of chronic constipation[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.85mL

1.77mL

0.89mL

17.71mL

3.54mL

1.77mL
参考文献

[1]Inoue T, et al. Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation. Eur J Pharmacol. 2017 Jul 5;806:25-31.

[2]Ohno H, et al. Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats. Xenobiotica. 2019 Apr;49(4):463-473.