Voclosporin

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Chemical Structure| 515814-01-4 同义名 : ISAtx-247
CAS号 : 515814-01-4
货号 : A1167646
分子式 : C63H111N11O12
纯度 : 98%
分子量 : 1214.62
MDL号 : MFCD30720011
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(41.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Voclosporin, also known as ISAtx-247, is a calcineurin (PP2B) (CN) inhibitor that acts as an immunosuppressant]1].As a calcineurin enzyme inhibitor, Voclosporin is more potent than cyclosporine in vitro[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.82mL

0.16mL

0.08mL

4.12mL

0.82mL

0.41mL

8.23mL

1.65mL

0.82mL
参考文献

[1]Abel MD, et al. ISATX247: a novel calcineurin inhibitor. J Heart Lung Transplant. 2001 Feb;20(2):161.

[2]Stalder M, et al. In vivo evaluation of the novel calcineurin inhibitor ISATX247 in non-human primates. J Heart Lung Transplant. 2003 Dec;22(12):1343-52.