NSC-87877

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Chemical Structure| 56990-57-9 同义名 : -
CAS号 : 56990-57-9
货号 : A1163721
分子式 : C19H13N3O7S2
纯度 : 99%+
分子量 : 459.45
MDL号 : MFCD09971104
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(34.82 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(43.53 mM)，配合低频超声，并水浴加热至45℃助溶
生物活性
描述 NSC-87877 is a potent inhibitor for both Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), showing IC50 values of 0.318 μM and 0.355 μM for Shp2 and Shp1, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.88mL

2.18mL

1.09mL

21.77mL

4.35mL

2.18mL
参考文献

[1]Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70.

[2]Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841.