Nω-Hydroxy-nor-Arg-OH·2HCl

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Chemical Structure| 291758-32-2 同义名 : Nω-Hydroxy-nor-L-arginine dihydrochloride; nor-NOHA dihydrochloride
CAS号 : 291758-32-2
货号 : A1153835
分子式 : C5H14Cl2N4O3
纯度 : 98%+
分子量 : 249.1
MDL号 : MFCD04036978
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(421.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 nor-NOHA dihydrochloride is a selective, reversible inhibitor of arginase. nor-NOHA dihydrochloride induces apoptosis in ARG2-expressing cells under hypoxic conditions. nor-NOHA dihydrochloride has antileukaemic activity and is also used to study endothelial dysfunction, immunosuppression and metabolism[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.01mL

0.80mL

0.40mL

20.07mL

4.01mL

2.01mL

40.14mL

8.03mL

4.01mL
参考文献

[1]Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254.