Pomalidomide-C6-COOH

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Chemical Structure| 2225940-50-9 同义名 : -
CAS号 : 2225940-50-9
货号 : A1148289
分子式 : C20H23N3O6
纯度 : 99%+
分子量 : 401.41
MDL号 : MFCD32063493
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(298.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Pomalidomide-C6-COOH serves as the pomalidomide-based cereblon (CRBN) ligand utilized in recruiting the CRBN protein. It can be linked to the protein ligand via a linker to form a PROTAC[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.49mL

0.50mL

0.25mL

12.46mL

2.49mL

1.25mL

24.91mL

4.98mL

2.49mL
参考文献

[1]Xiaojuan Qu, et al. Effective degradation of EGFRL858R+T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems. Eur J Med Chem. 2021.