Glycerol phenylbutyrate
产品说明书
 |
同义名 : | HPN-100; GT4P |
| CAS号 : | 611168-24-2 | |
| 货号 : | A1147704 | |
| 分子式 : | C33H38O6 | |
| 纯度 : | 97% | |
| 分子量 : | 530.65 | |
| MDL号 : | MFCD28016960 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(197.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 无水乙醇: 45 mg/mL(84.8 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Glycerol phenylbutyrate (GPB) acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02 and functions as a next-generation ammonia scavenger. GPB is recognized for its potential in treating hyperammonemia and may also hold therapeutic potential for conditions such as chronic hepatic encephalopathy and other inherited metabolic disorders[1].[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.88mL 0.38mL 0.19mL |
9.42mL 1.88mL 0.94mL |
18.84mL 3.77mL 1.88mL |
| 参考文献 |
|---|