D-I03

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Chemical Structure| 688342-78-1 同义名 : -
CAS号 : 688342-78-1
货号 : A1145758
分子式 : C23H36N6S
纯度 : 99%+
分子量 : 428.64
MDL号 : MFCD14739485
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(116.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 D-I03, with a KD of 25.8 µM, is a selective inhibitor of RAD52. It specifically targets RAD52-dependent single-strand annealing (SSA) and D-loop formation, with IC50s of 5 µM and 8 µM, respectively. D-I03 inhibits the growth of BRCA1- and BRCA2-deficient cells, and prevents the formation of damage-induced RAD52 foci, while not affecting RAD51 foci induced by Cisplatin[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.33mL

0.47mL

0.23mL

11.66mL

2.33mL

1.17mL

23.33mL

4.67mL

2.33mL
参考文献

[1]Huang F, et al. Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors. Nucleic Acids Res. 2016 May 19;44(9):4189-99.

[2]Hengel SR, et al. Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.

[3]Sullivan-Reed K, et al. Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Rep. 2018 Jun 12;23(11):3127-3136.