13-Methylberberine chloride

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Chemical Structure| 54260-72-9 同义名 : 13-Methylberberinium chloride; 13-Methylberberine (chloride); 13-MB
CAS号 : 54260-72-9
货号 : A1144432
分子式 : C21H20ClNO4
纯度 : 99%+
分子量 : 385.84
MDL号 : MFCD32197205
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(46.65 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 13-Methylberberine chloride (13-Methylberberinium chloride), an analogue of berberine, exhibits both anti-adipogenic and antitumor properties. It boosts IL-12 production and suppresses iNOS expression at the posttranscriptional level in LPS-stimulated macrophages[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.96mL

2.59mL

1.30mL

25.92mL

5.18mL

2.59mL
参考文献

[1]Chow YL, et al. 13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cells. Sci Rep. 2016 Dec 5;6:38129.

[2]Iwasa K, et al. In vitro cytotoxicity of the protoberberine-type alkaloids. J Nat Prod. 2001 Jul;64(7):896-8.

[3]Lee DU, et al. Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-alpha, iNOS, and IL-12 production in LPS-stimulated macrophages. Life Sci. 2003 Aug 1;73(11):1401-12.