Gap 26

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Chemical Structure| 197250-15-0 同义名 : Gap Junction Peptide 26; VCYDKSFPISHVR; Gap 26 (trifluoroacetate salt)
CAS号 : 197250-15-0
货号 : A1142866
分子式 : C70H107N19O19S
纯度 : 99%+
分子量 : 1550.77
MDL号 : MFCD06411601
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 50 mg/mL(32.24 mM)，配合低频超声助溶
生物活性
描述 Gap 26 is a connexin mimetic peptide, working as a Gap junction blocker. Gap26 inhibited electrical coupling in cell pairs mediated by gap junctions after exposure for 30 min, but inhibited hemichannel currents evoked in low Ca2+ solution with a response time of less than 5 min when applied to single cells. Gap 26 reduced the size of InsP3-triggered intercellular calcium waves at concentration of 0.25mg/ml post 30 minutes in RBE4 cells, blocked Photoliberating InsP3 triggered ATP release, but did not inhibit the gap junctional coupling between the cells.
作用机制 Gap 26 is a connexin mimetic peptide corresponding to short conserved extracellular loop sequences of connexins as reversible inhibitor of gap junctional intercellular communication.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.64mL

0.13mL

0.06mL

3.22mL

0.64mL

0.32mL

6.45mL

1.29mL

0.64mL
参考文献

[1]Desplantez T, Verma V, et al. Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels. Pharmacol Res. 2012 May;65(5):546-52.

[2]Braet K, Vandamme W, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33(1):37-48.