PRE-084 HCl

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Chemical Structure| 75136-54-8 同义名 : PRE-084 (hydrochloride); PRE-084 hydrochloride
CAS号 : 75136-54-8
货号 : A111935
分子式 : C19H28ClNO3
纯度 : 99%
分子量 : 353.88
MDL号 : -
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(98.9 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(84.77 mM)，配合低频超声，并水浴加热至45℃助溶
生物活性
描述 PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.13mL

2.83mL

1.41mL

28.26mL

5.65mL

2.83mL
参考文献

[1]Peviani M, Salvaneschi E, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-32.

[2]Su TP, Wu XZ, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259(2):543-50.