NSC 74859

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Chemical Structure| 501919-59-1 同义名 : S3I-201
CAS号 : 501919-59-1
货号 : A111782
分子式 : C16H15NO7S
纯度 : 99%+
分子量 : 365.36
MDL号 : MFCD09907564
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(287.39 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • STAT3

    STAT3, IC50:86 μM
描述 NSC 74859 (S3I-201) acts as a selective inhibitor of Stat3, demonstrating an IC50 of 86 μM[1].
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
A459 100 nM Apoptosis Assay 24 h induces cell apoptosis co-treated with BEZ235 24472538
BT474R 50 μM Function Assay 10-60 d inhibits STAT3 activity 25327561
GC 50-125 μM Growth Inhibition Assay 72 h attenuates the cell growth in a dose-dependent manner 25774503
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.74mL

0.55mL

0.27mL

13.69mL

2.74mL

1.37mL

27.37mL

5.47mL

2.74mL
参考文献

[1]Siddiquee K, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6.

[2]Lin L, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling. Oncogene. 2009 Feb 19;28(7):961-72.