COH-SR4

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Chemical Structure| 73439-19-7 同义名 : -
CAS号 : 73439-19-7
货号 : A1103292
分子式 : C13H8Cl4N2O
纯度 : 99%+
分子量 : 350.03
MDL号 : MFCD01566238
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(342.83 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 COH-SR4 activates AMPK and exhibits strong anti-proliferative effects against leukemia, melanoma, breast, and lung cancers. It hinders adipocyte differentiation by activating AMPK. COH-SR4 is a valuable tool for studying obesity and associated metabolic disorders[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.28mL

2.86mL

1.43mL

28.57mL

5.71mL

2.86mL
参考文献

[1]James L Figarola, et al. Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation. Int J Mol Med. 2013 May;31(5):1166-76.

[2]James Lester Figarola, et al. COH-SR4 Reduces Body Weight, Improves Glycemic Control and Prevents Hepatic Steatosis in High Fat Diet-Induced Obese Mice. PLoS One. 2013; 8(12): e83801.