H-Hyp-OMe·HCl

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Chemical Structure| 40216-83-9 同义名 : H-Hyp-OMe hydrochloride
CAS号 : 40216-83-9
货号 : A109292
分子式 : C6H12ClNO3
纯度 : 95%
分子量 : 181.62
MDL号 : MFCD00080855
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 H-Hyp-OMe hydrochloride serves as a non-cleavable ADC linker in the synthesis of antibody-drug conjugates (ADCs). It is also utilized as an alkyl chain-based PROTAC linker, contributing to the development of PROTACs (Proteolysis Targeting Chimeras)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.51mL

1.10mL

0.55mL

27.53mL

5.51mL

2.75mL

55.06mL

11.01mL

5.51mL
参考文献

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.