Amlodipine maleate

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Chemical Structure| 88150-47-4 同义名 : Amvaz; UK-48340 maleate
CAS号 : 88150-47-4
货号 : A107087
分子式 : C24H29ClN2O9
纯度 : 98%
分子量 : 524.95
MDL号 : MFCD02259457
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 115 mg/mL(219.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Calcium Channel
描述 Amlodipine maleate is a dihydropyridine calcium channel blocker that serves as an orally active antianginal agent. It functions by blocking voltage-dependent L-type calcium channels, effectively inhibiting the initial influx of calcium ions. This drug is utilized in research focused on high blood pressure and cancer[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.52mL

1.90mL

0.95mL

19.05mL

3.81mL

1.90mL
参考文献

[1]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12.

[2]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87.

[3]Kishen G. Bulsara, et al. Amlodipine.

[4]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586.