ICCB-19 HCl
产品说明书
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同义名 : | ICCB-19 hydrochloride |
| CAS号 : | 1803605-68-6 | |
| 货号 : | A1066030 | |
| 分子式 : | C12H22ClN3OS | |
| 纯度 : | 99%+ | |
| 分子量 : | 291.84 | |
| MDL号 : | MFCD28145281 | |
| 存储条件： |
Pure form Keep in dark place,Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 85 mg/mL(291.25 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(342.65 mM) |
| 生物活性 | |||
|---|---|---|---|
| 描述 | ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. It binds to the N-terminal domain of TRADD (TRADD-N), disrupting its interaction with both TRADD-C and TRAF2. ICCB-19 hydrochloride indirectly inhibits RIPK1 kinase activity, effectively inducing autophagy and the degradation of long-lived proteins[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.43mL 0.69mL 0.34mL |
17.13mL 3.43mL 1.71mL |
34.27mL 6.85mL 3.43mL |
| 参考文献 |
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