L 152804

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Chemical Structure| 6508-43-6 同义名 : -
CAS号 : 6508-43-6
货号 : A1058930
分子式 : C23H26O4
纯度 : 95%
分子量 : 366.45
MDL号 : MFCD00184132
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(327.47 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 L 152804 is an orally active, selective neuropeptide Y5 receptor (NPY5-R) antagonist with a Ki value of 26 nM against hY5. L 152804 results in weight loss in diet-induced obese mice through modulation of food intake and energy expenditure[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.64mL

2.73mL

1.36mL

27.29mL

5.46mL

2.73mL
参考文献

[1]Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73.

[2]Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14.