Erdosteine

产品说明书

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Chemical Structure| 84611-23-4 同义名 : RV 144; Erdostin; PV 144
CAS号 : 84611-23-4
货号 : A103530
分子式 : C8H11NO4S2
纯度 : 98%
分子量 : 249.31
MDL号 : MFCD00867664
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(200.55 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 6.5 mg/mL(26.07 mM)，配合低频超声助溶
动物实验配方：

PO 0.5% CMC-Na 37 mg/mL suspension

生物活性
描述 Erdosteine effectively inhibits lipopolysaccharide (LPS)-induced NF-κB activation, demonstrating its anti-inflammatory capabilities[1].[2]. Additionally, Erdosteine is recognized for its muco-modulatory, antibacterial, anti-inflammatory, and antioxidant effects[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03368053 Infection, Human Immunodeficie... 展开 >>ncy Virus 收起 << Phase 1 Completed - Belgium ... 展开 >> GSK Investigational Site Gent, Belgium, 9000 收起 <<
NCT02109354 HIV Infection Phase 1 Unknown April 2016 South Africa ... 展开 >> Emavundleni Desmond Tutu HIV Centre CRS Cape Town, Western Cape, South Africa, 7750 Aurum Institute for Health Research Klerksdorp, South Africa, 2570 Perinatal HIV Research Unit Soweto, South Africa, 2013 收起 <<
NCT00223080 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.01mL

0.80mL

0.40mL

20.06mL

4.01mL

2.01mL

40.11mL

8.02mL

4.01mL
参考文献

[1]Park JS, et al. Anti-inflammatory Effect of Erdosteine in Lipopolysaccharide-Stimulated RAW 264.7 Cells. Inflammation. 2016 Aug;39(4):1573-81.

[2]Oktar S, et al. Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice. Toxicol Ind Health. 2010 Aug;26(7):433-8.

[3]Recipharm’s proprietary molecule Erdosteine recognised as COPD treatment