G-5555

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Chemical Structure| 1648863-90-4 同义名 : -
CAS号 : 1648863-90-4
货号 : A102618
分子式 : C25H25ClN6O3
纯度 : 99%
分子量 : 492.96
MDL号 : MFCD28506227
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(50.71 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 G-5555 is a selective PAK1 inhibitor (Ki=3.7 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.14mL

2.03mL

1.01mL

20.29mL

4.06mL

2.03mL
参考文献

[1]Rudolph J, Murray LJ, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41.

[2]Ndubaku CO, Crawford JJ, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.