Fosphenytoin disodium
产品说明书
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同义名 : | Cl-982; ACC-9653; Fosphenytoin (sodium salt) |
| CAS号 : | 92134-98-0 | |
| 货号 : | A102515 | |
| 分子式 : | C16H13N2Na2O6P | |
| 纯度 : | 99%+ | |
| 分子量 : | 406.24 | |
| MDL号 : | MFCD00948765 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 100 mg/mL(246.16 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Fosphenytoin (disodium) is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration[1]. In fully kindled female Wistar rats, fosphenytoin dose-dependently increased the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold were reduced only after the highest does of fosphenytoin tested (84 mg/kg)[2]. Intravenous injection of fPHT (fosphenytoin) (15 and 30 mg/kg) alleviated HSV-1(herpes simplex virus type 1)-induced provoked pain (allodynia and hyperalgesia). fPHT, diclofenac, and pregabalin significantly suppressed HSV-1-induced spontaneous pain-like behaviors. Among them, high-dose fPHT (30 mg/kg) showed the strongest suppression[3]. A single intramuscular injection of fosphenytoin (20 phenytoin equivalents/kg) does not prevent seizures or neurologic deficits in childhood acute nontraumatic coma[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.46mL 0.49mL 0.25mL |
12.31mL 2.46mL 1.23mL |
24.62mL 4.92mL 2.46mL |
| 参考文献 |
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