Enoxacin Sesquihydrate

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Chemical Structure| 84294-96-2 同义名 : 依诺沙星半水合物 ;CI-919 hydrate; AT-2266 hydrate; Enoxacin hydrate
CAS号 : 84294-96-2
货号 : A102347
分子式 : C30H40F2N8O9
纯度 : 98%
分子量 : 694.68
MDL号 : MFCD01747755
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(2.88 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

1M NaOH: 100 mg/mL(143.95 mM)，配合低频超声，并调节pH至11
生物活性
描述 Enoxacin (Sesquihydrate) is a new quinolone carboxylic acid compound. It inhibited 90% Escherichia coli, Klebsiella sp., Aeromonas sp., Enterobacter spp., Serratia spp., Proteus mirabilis, and Morganella morganii at less than or equal to 0.8 micrograms/ml. Enoxacin inhibited organisms resistant to cefotaxime, moxalactam, gentamicin, and piperacillin[3]. It has a broad spectrum of in vitro antibacterial activity, and is particularly potent against Gram-negative organisms and staphylococci. Significantly (p less than 0.01) more clinical and/or bacteriological cures were effected by enoxacin than pipemidic acid in acute cystitis and complicated urinary tract infection[4]. Enoxacin and bis-enoxacin trigger the release of EVs (Extracellular vesicles) from 4T1 cancer cells that inhibit osteoclastogenesis[5]. UVA (ultraviolet A) irradiation activates enoxacin, after which activated enoxacin induces apoptosis of AsPC1 cells through generation of reactive oxygen species[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.44mL

0.29mL

0.14mL

7.20mL

1.44mL

0.72mL

14.40mL

2.88mL

1.44mL
参考文献

[1]Wijnands WJ, Vree TB, Van Herwaarden CL. Enoxacin decreases the clearance of theophylline in man. Br J Clin Pharmacol. 1985 Dec;20(6):583-8.

[2]Chin NX, Neu HC. In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim. Antimicrob Agents Chemother. 1983 Nov;24(5):754-63.

[3]Chin NX, Neu HC. In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim. Antimicrob Agents Chemother. 1983;24(5):754–763

[4]Henwood JM, Monk JP. Enoxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1988;36(1):32–66

[5]Vracar TC, Zuo J, Park J, et al. Enoxacin and bis-enoxacin stimulate 4T1 murine breast cancer cells to release extracellular vesicles that inhibit osteoclastogenesis. Sci Rep. 2018;8(1):16182

[6]Nishi K, Kato M, Sakurai S, Matsumoto A, Iwase Y, Yumita N. Enoxacin with UVA Irradiation Induces Apoptosis in the AsPC1 Human Pancreatic Cancer Cell Line Through ROS Generation. Anticancer Res. 2017;37(11):6211–6214