Apiin

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Chemical Structure| 26544-34-3 同义名 : 芹菜苷 ;Apigenin 7-apisoylglucoside; Apigenin 7-O-apioglucoside
CAS号 : 26544-34-3
货号 : A101993
分子式 : C26H28O14
纯度 : 99%+
分子量 : 564.49
MDL号 : MFCD00016941
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(186.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells[3]. Apiin showed to be the most abundant phenolic compound in the extract. It also revealed the presence of many coumaric acid derivatives[4]. Apiin had a remarkable scavenging activity on MDA (maleic dialdehyde) and LPF (lipofuscin), promoted TAOC (total antioxidant capacity) and significantly enhanced the activities of SOD (superoxide dismutase), GSH-Px (glutathione peroxidase) and CAT (catalase) [5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.86mL

1.77mL

0.89mL

17.72mL

3.54mL

1.77mL
参考文献

[1]Kasthuri J, Veerapandian S, Rajendiran N. Biological synthesis of silver and gold nanoparticles using apiin as reducing agent. Colloids Surf B Biointerfaces. 2009 Jan 1;68(1):55-60.

[2]Mencherini T, Cau A, et al. An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties. J Pharm Pharmacol. 2007 Jun;59(6):891-7.

[3]Mencherini T, Cau A, Bianco G, Della Loggia R, Aquino RP, Autore G. An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties. J Pharm Pharmacol. 2007 Jun;59(6):891-7

[4]Frattani FS, Assafim M, Casanova LM, de Souza JE, Chaves DSA, Costa SS, Zingali RB. Oral treatment with a chemically characterized parsley (Petroselinum crispum var. neapolitanum Danert) aqueous extract reduces thrombi formation in rats. J Tradit Complement Med. 2020 Apr 17;11(3):287-291

[5]Li P, Jia J, Zhang D, Xie J, Xu X, Wei D. In vitro and in vivo antioxidant activities of a flavonoid isolated from celery (Apium graveolens L. var. dulce). Food Funct. 2014 Jan;5(1):50-6