Flunixin meglumine

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Chemical Structure| 42461-84-7 同义名 : Flunixin (meglumine); Banamine; Flunixin-S; Flumeglumine; NIH 10250; Flunixin Meglumin
CAS号 : 42461-84-7
货号 : A101184
分子式 : C21H28F3N3O7
纯度 : 98%
分子量 : 491.46
MDL号 : MFCD01725419
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(213.65 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(101.74 mM)，配合低频超声助溶
生物活性
靶点

  • COX
描述 Flunixin Meglumine (FM) is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. Intravenous FM, 1.1 mg kg-1, significantly inhibited carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, < 0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h. Flunixin meglumine significantly inhibited the rise in skin temperature but had a limited effect on exudate WBC(white blood cell). Flunixin meglumine was a more potent COX inhibitor than PBZ (phenylbutazone) and was more selective for the inducible form of COX in vivo[3]. Administration of flunixin meglumine improved pregnancy rates in excitable recipient cows following embryo transfer without affecting the proportion of non-pregnant cows returning to estrus[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.17mL

2.03mL

1.02mL

20.35mL

4.07mL

2.03mL
参考文献

[1]Bryant CE, Farnfield BA, et al. Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res. 2003 Feb;64(2):211-5.

[2]Anderson KL, Smith AR, et al. Efficacy of flunixin meglumine for the treatment of endotoxin-induced bovine mastitis. Am J Vet Res. 1986 Jun;47(6):1366-72.

[3]Cheng Z, Nolan AM, McKellar QA. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998;22(4):353-366

[4]Kasimanickam RK, Hall JB, Estill CT, et al. Flunixin meglumine improves pregnancy rate in embryo recipient beef cows with an excitable temperament. Theriogenology. 2018;107:70-77