ML351

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Chemical Structure| 847163-28-4 同义名 : CID 664510
CAS号 : 847163-28-4
货号 : A1002813
分子式 : C15H11N3O
纯度 : 98%
分子量 : 249.27
MDL号 : MFCD04183120
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(200.59 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 ML351 is a novel chemotype and the first reported selective inhibitor of 15-LOX-1 with IC50 value of 200 nM. It is a tight binding, mixed inhibitor which could protect against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.01mL

0.80mL

0.40mL

20.06mL

4.01mL

2.01mL

40.12mL

8.02mL

4.01mL
参考文献

[1]Ganesha Rai, Netra Joshi, et al. Discovery of ML351, a Potent and Selective Inhibitor of Human 15-Lipoxygenase-1.