Triptonide, a natural product isolated and purified from the herb of Tripterygium wilfordii Hook.f. with antileukemic, antitumor, anti-inflammatory activities, is effective in the treatment of autoimmune diseases. Triptonide can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin.

Astragaloside I is a natural product isolated from Astragalus.

Eriocitrin is a natural product isolated and purified from the fruits of Citrus sinensis (L.) Osbeck with antioxidative activity.

C-82 is an active metabolite of PRI-724 which selectively inhibits the CBP/β-catenin interaction.

3-(2-Hydroxyphenyl)-2-propenal is a natural product isolated and purified from the barks of Cinnamomum cassia.

β-catenin-IN-2 is a potent β-catenin inhibitor that can be used for the study of colorectal cancer.

beta-Catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma.

Chelerythrine, a natural product isolated and purified from the herbs of Chelidonium majus with potent antimanic, antiproliferatvie and antitumor effect, can inhibit telomerase activity, and is a well-known protein kinase C inhibitor.

PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.

Salinomycin, an antibiotic potassium ionophore, is an anti-coccidial drug and an autophagy modulator. It is also an inhibitor of Wnt/β-catenin signaling.