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TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD-Yap protein-protein interaction. TED-347 inhibits TEAD4-Yap1 interaction with an EC50 value of 5.9 μM.
YAP-TEAD Inhibitor 1 is an inhibitor of this YAP-TEAD protein-protein interaction which has potential usage in treatment of YAP-involved cancers with IC50 of 25nM.
Verteporfin, a benzoporphyrin derivative monoacid ring A, inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent.
Tags: YAP | 干细胞 | Stem Cells/Wnt | YAP 相关产品
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