JW74 is an efficient and specific inhibitor of the canonical Wnt signaling.

Echinacoside is a naturally occuring caffeic acid glycoside with antiapoptotic effect.

Astragaloside I is a natural product isolated from Astragalus.

Methyl vanillate has ability to increase bone mass and activate wnt/β-catenin pathway. It can act as a potential lead anabolic agent for anti-osteoporosis drugs.

BML-284 is a Wnt signaling activator with EC50 value of 0.7 μM for inducing β-catenin and TCF-dependent transcriptional activity.

CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.

iCRT3 can inhibit both Wnt and β-catenin-responsive transcription.

for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].

IWP-2 is an inhibitor of porcn-mediated Wnt palmitoylation and secretion with IC50 of 27 nM.

IWP 4 is a potent inhibitor of Wnt/β-catenin signaling with IC50 of 25 nM.

KY02111 can inhibit Wnt signaling and promote differentiation of hPSCs to cardiomyocytes.