Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin increases collagen synthesis, caused by up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production.

Vaccarin, a natural product isolated and purified from the seeds of Vaccaria segetalis, can significantly promote neovascularization by enhancing protein expression of p-Akt , p‑Erk, and CD31, and may be able to selectively protect vascular endothelium from dysfunction induced by H2O2.