Sweroside, a natural product isolated and purified from the herbs of Swertia bimaculata with strong hepatoprotective, anti-osteoporotic, insulin-mimicking, and wound-healing effects, can inhibit potent melanogenesis in melan-a cells at 300uM without cytotoxicity, also decreases tyrosinase, tyrosinase-related protein-1 (TRP-1) and TRP-2 protein production in melan a cells.

Trifolirhizin is purified from the roots of sophora flavescens L. that possesses potential anti-inflammatory and anti-cancer activities.

2,4-Dihydroxyhydrocinnamic Acid shows tyrosinase inhibition activity when mixed with l-ascorbic acid, it is a natural product isolated and purified from the herbs of Juniperus formosana.

3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth.

beta-Hydroxypropiovanillone is a natural product isolated and purified from the barks of Pinus yunnanensis showing potent tyrosinase inhibitory activity.

4-Hexylbenzene-1,3-Diol is a mushroom tyrosinase inhibitor with local anaesthetic and antiseptic activities.

Methyl 3-(2,4-dihydroxyphenyl)propionate, a natural product isolated and purified from the herbs of Juniperus formosana, has inhibitory effects on tyrosinase, antioxidant ability, and lightening effect of ultraviolet B (UVB)-induced hyperpigmentation.

4-Butylresorcinol, a phenol derivative, is an inhibit of tyrosinase with IC50 of 11.27 μM.

Gnetol is a tyrosinase inhibitor isolated from genus Gnetum.