Eleutherin, a benzoisochromanequinone, is extracted from bulbs of eleutherine bulbosa with limited antibiotic activity.

SW044248 is a noncanonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.

Temafloxacin is a fluoroquinolone antibiotic drug which was withdrawn from sale in the United States shortly after its approval in 1992 because of serious adverse effects resulting in three deaths.

Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.

Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Pixantrone dimaleate is an experimental antineoplastic drug.

Indotecan is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.

Valrubicin is a chemotherapy drug used to treat bladder cancer.

Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.

Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity (IC50=1.2 nM).

Bisantrene is a highly effective antitumor drug, targets eukaryotic typeII topoisomerases.

Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family.