Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

Difluoxacin HCl is a quinolone antimicrobial antibiotic and an inhibitor of Topo II.

Finafloxacin HCl, an 8-cyano subclass of fluoroquinolone, has demonstrated potent antibacterial activity in a range of in vitro and in vivo models against Gram-negative and Gram-positive bacterial isolates.

Belotecan hydrochloride, a synthetic and water-soluble camptothecin derivative, is inhibitor of topoisomerase I.

Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 1.25±0.13, 0.67±0.06, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.44±0.03, 0.49±0.04, and 1.48±0.62 μM for Breast adenocarcinoma MCF-7, Leukemia HL-60, Breast adenocarcinoma MCF-7, Leukemia HL-60, Neuroblastoma IMR-32, Neuroblastoma UKF-NB-3, Neuroblastoma UKF-NB-4, and Glioblastoma U87MG cell, respectively.

Ellipticine HCl is a potent antineoplastic agent and inhibits DNA topoisomerase II activities.

Exatecan is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself.

Balofloxacin, a quinolone antibiotic, can interfer with DNA gyrase and inhibit the synthesis of bacterial DNA.

Exatecan mesylate is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself.

A choleretic.

Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml).

Podophyllotoxin is a competitive microtubule assembly inhibitor.