Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM.

Pomalidomide can inhibit LPS-induced TNF-α release with IC50 of 13 nM in PBMCs.

Necrostatin-1 is an inhibitor of RIP1 and can decrease TNF-α-induced necroptosis with EC50 of 490 nM.

QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively.

Apremilast is a small molecule inhibitor of PDE4 with an IC50 value of 74 nM.

GSK2982772 is an inhibitor of receptor interacting protein 1 (RIP1) with IC50 of 16 nM and it is used for the treatment of inflammatory diseases.

Thalidomide targets to CRBN with IC50 of 8.5 nM. It can inhibit biosynthesis of TNF-α and has anti-angiogenic and immunosuppressive effects.

Acetylcysteine is an inhibitor of ROS and the production of TNF. It is a pharmaceutical drug and nutritional supplement used as mucolytic agent.

GSK'481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.