LY2109761 is a selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively and is shown to negatively affect the phosphorylation of Smad2.

LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, exhibits 7-fold selectivity over TGFβR-II.