R 59-022 is a diacylglycerol kinase inhibitor with IC50 of 2.8 μM. R 59-022 is a 5-HTR antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[1][2][3][4].

Bisindolylmaleimide IV is an inhibitor of protein kinase C.

Juglone significantly inhibits the proliferation and induce the apoptosis of SiHa cells and Caski cells, stimulates suicidal erythrocyte death or eryptosis at least in part by upregulation of ceramide abundance, energy depletion and activation of PKC, and prevents high-fat diet-induced liver injury and nerve inflammation in mice through inhibition of inflammatory cytokine secretion, NF-kappa B activation and endotoxin production. It's a natural product isolated and purified from the barks of Juglans regia L..

Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively[1]. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases[2].

PKCβ Inhibitor is a potent, reversible and ATP-competitive PKCβ inhibitor with IC50 values of 5nM and 21nM for PKCβII and βI, respectively.

NIBR3049, also known as TCS-21311, is a potent and selective JAK3 inhibitor IC50 values of 8 nM..

Hispidin is a polyphenol originally isolated from P. hispidus that has diverse biological activities, including antioxidant, anti-inflammatory, and cytoprotective properties.

CMPD101 is a selective GRK2/3 inhibitor with IC50 values of 32 and 54 nM for GRK3 and GRK2, respectively.

α-Tocopherol is a type of vitamin E and an antagonist of PKCα.

SRI-011381 is an agonist of TGF-beta signaling pathway, can be used in the treatment of Alzheimer’s disease.

EW-7197 HCl is a small-molecule ATP-competitive inhibitor of TGFβRI (ALK5) with an IC50 of 12.9 nM.