GS-9973 is a Syk inhibitor with IC50 value of 7.7 nM which is used for the treatment of autoimmune and oncology indications.

PRT062607 HCl is an inhibitor of SYK with IC50 of 1 nM.

PRT-060318 is an inhibitor of Syk with IC50 of 4 nM. It is used to treat heparin-induced thrombocytopenia (HIT).

R788 Disodium is a Syk inhibitor with IC50 of 41 nM. It is the prodrug of metabolite R406 with immunomodulatory activity.

RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling.

TAK-659 HCl is a selective inhibitor of spleen tyrosine kinase (Syk) with IC50 of 3.2 nM.

PRT062607 is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM with > 80-fold selectivity for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.

R112, an ATP-competitive inhibitor, can inhibit Syk kinase with Ki of 96 nM.

ZAP-180013 is inhibitor of zeta-chain-associated protein kinase 70 (ZAP-70) with IC50 of 1.8 μM. It inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs).

R406 is an inhibitor of Syk with IC50 of 41 nM.

R406 benzenesulfonate is a selective inhibitor of Syk with IC50 of 41 nM.

Piceatannol, a natural stilbene, is selective Syk inhibitor extracted from the rhizomes of Polygonum cuspidatum Sieb. et Zucc..

Cerdulatinib is a multiple tyrosine kinase inhibitor with IC50 values of 12 nM/6 nM/8 nM and 0.5 nM, for JAK1/JAK2/JAK3 and TYK2, also shows potency against MST1, ARK5, MLK1, Fms. Syk, etc. with IC50 values ranging in 4-51 nM.

Fostamatinib, a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.

BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.

R788 disodium, the disodium form of R788, is a Syk inhibitor with IC50 of 41 nM.