CAY10602 is a SIRT1 activator.

Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.

DL-800 is an allosteric and selective SIRT6 activator with EC50 of 10.3μM.

SRT1460 is a SIRT1 activator with EC50 value of 2.9μM in an in vitro fluorescence polarization assay.

SRT2104 is an activator of SIRT1 which is involved in the regulation of energy homeostasis.

SIRT5 inhibitor 1 (compound 49) is a very potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.

Dihydrocoumarin, a natural product isolated and purified from the leaves of Southern sweet-grass., is widespread used as a flavoring agent in beverages, gelatins, puddings, candy, and other food items. It is also as a fragrance in perfumes, creams, and cosmetics.

SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1.

Triacetylresveratrol is a prodrug of resveratrol with multiple targets including sirt, COX, IKK β and LOX, etc..

API-1 is a selective Akt/PKB inhibitor and shows antitumor activity.

Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively.

Fisetin is an active flavonol that can be used in the synthesis of pharmaceutical with anti-inflammatory and antiproliferative activities.