L-Rhamnose, a natural product isolated and purified from the flowers of Scphora japonica L., increases serum propionate after long-term supplementation, but lactulose does not raise serum acetate, has anticancer potential, they exert a significant suppressive effect on tumour growth, and exhibits potent excellent sodium-glucose transporter (SGLT1 and SGLT2) inhibition activity.

Ipragliflozin is a selective inhibitor of SGLT2 with IC50 of 14 nM for hSGLT2.

LX4211 is an inhibitor of SGLT2 and SGLT1 with antidiabetic activity.

Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. A drug for the treatment of type 2 diabetes mellitus[2].

Ipragliflozin (L-Proline) selectively inhibits SGLT2 with IC50 of 2.8 nM.

Dapagliflozin propanediol is an inhibitor of SGLT2 that is used for the treatment of of type 2 diabetes mellitus.

Bexagliflozin is an inhibitor of SGLT2 with IC50 value of 2 nM.

Trilobatin, a natural product isolated and purified from the herbs of Lithocarpus pachyphyllus with anti-oxidant effect, potentially inhibits the LPS-induced inflammatory response by suppressing the NF-κB signaling pathway and is a potential effective α-glucosidase inhibitor for management of postprandial hyperglycemia with less side effect.

PF-04971729 is a selective sodium-dependent glucose cotransporter (SGLT) inhibitor which selectively targets SGLT2.

Empagliflozin is a selective inhibitor of SGLT-2 with IC50 of 3.1 nM.

Canagliflozin selectively inhibits SGLT2 with IC50 of 2.2 nM.

Canagliflozin is a novel C-glucoside with thiophene ring.

Phlorizin is an inhibitor of hSGLT1 (Ki=300 nM) and hSGLT2 (Ki= 39 nM). It can be found in a number of fruit trees.

Phloretin, a dihydrochalcone flavonoid, can inhibit the active transport of glucose into cells by SGLT1 and SGLT2. It is mainly found in fruit and roots of apple tree.