AZD3839 is an inhibitor of BACE1 with IC50 of 23.6 uM.

CHF5074 is a γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.

PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.

Tenuifolin, a natural product isolated and purified from the root of Polygala tenuifolia Willd., has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.

E 2012 is a potent γ-secretase modulator.

LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.

Verubecestat is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.

RO4929097 is an inhibitor of γ secretase, the IC50s of Aβ40 and notch are 14 nM and 5 nM, respectively.

NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. NB-360 stopped accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared.

NGP555 is a γ-secretase modulator.

Compound E is an inhibitor of γ-Secretase.

Scoulerine, a natural product isolated and purified from the herbs of Corydalis dubia., shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively.