K-Ras G12C-IN-3 is an irreversible inhibitor of mutant K-ras G12C.

NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of ~50 μM and does not inhibit the closely related targets, Cdc42 or RhoA.

ARS-1323-alkyne is a KRAS^G12C occupancy probe. It is a chemical probe that enables measurement of live-cell KRAS^G12C covalent inhibition kinetics.

CASIN is an inhibitor of GTPase Cdc42 with IC50 of 2 μM that can generat a rejuvenated phenotype of HSCs.

MDK-3017 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.

MRTX1257 is a selective, covalent K-Ras G12C inhibitor with oral activity in animal models of cancer.

Kobe0065 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with Ki of 46 ± 13 μM.

DUN09716 is a potent KRAS inhibitor with Kd value of 92μM that blocks the formation of GTP-KRAS and downstream activation of KRAS.

1A-116 is a specific Rac1 inhibitor.

KY1220 inhibits Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 cells and it can destabilize both β-catenin and Ras.

Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations and also leads to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.