货号:A723646
同义名:
SKQ1; SKQ1 (bromide)
SKQ1 is a mitochondria-targeted plastoquinone antioxidant which can prevent the deleterious effect of Aβ on LTP through intraperitoneal injection at very low concentrations (250 nmol/kg body weight). It is considered as a promising candidate for the treatment of early-stage Alzheimer's disease.
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描述 | Reactive oxygen species (ROS) are a group of highly reactive oxygen-containing chemicals. Normally, the intracellular ROS level is undertight control by various antioxidants. Any disruption in the oxidation–antioxidation balance will lead to oxidative stress which is associated with a wide spectrum of human disorders. SkQ1 is a new antioxidant with the highest mitochondrion membrane penetrating ability and potent antioxidant capability. SkQ1 up-regulated production of angiogenic factors in serum and tumor of PDAC (pancreatic ductal adenocarcinoma)-bearing mice. Furthermore, an increase was observed in VEGF (vascular endothelial growth factor) concentration in serum of mice treated with SkQ1. Also, an increase in the IL-6 and IL-13 amount was found in the SkQ1 treated groups and the TGF-β amount was decreased in the pretreatment setting supporting the fact that SkQ1 can directly influence cytokine production from immune cells. This can be further illustrated by a significant decrease in the TNF-α and IFN-α production and a tendency to decrease the production of IL-6 and IL-10. Moreover, this drug at 500 nM concentration reduced heavily the proliferation of human PDAC cells[1]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.62mL 0.32mL 0.16mL |
8.10mL 1.62mL 0.81mL |
16.19mL 3.24mL 1.62mL |
CAS号 | 934826-68-3 |
分子式 | C36H42BrO2P |
分子量 | 617.6 |
SMILES Code | O=C(C(CCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=C4)C(C)=C(C)C4=O.[Br-] |
MDL No. | MFCD29477502 |
别名 | SKQ1; SKQ1 (bromide) |
运输 | 蓝冰 |
InChI Key | WYHFWTRUGAFNKW-UHFFFAOYSA-M |
Pubchem ID | 16679091 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Inert atmosphere, store in freezer, under -20°C |
溶解方案 |
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