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Visomitin {[allProObj[0].p_purity_real_show]}

货号:A723646 同义名: SKQ1; SKQ1 (bromide)

SKQ1 is a mitochondria-targeted plastoquinone antioxidant which can prevent the deleterious effect of Aβ on LTP through intraperitoneal injection at very low concentrations (250 nmol/kg body weight). It is considered as a promising candidate for the treatment of early-stage Alzheimer's disease.

Visomitin 化学结构 CAS号:934826-68-3
Visomitin 化学结构
CAS号:934826-68-3
Visomitin 3D分子结构
CAS号:934826-68-3
Visomitin 化学结构 CAS号:934826-68-3
Visomitin 3D分子结构 CAS号:934826-68-3
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Visomitin 纯度/质量文件 产品仅供科研

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Visomitin 生物活性

描述 Reactive oxygen species (ROS) are a group of highly reactive oxygen-containing chemicals. Normally, the intracellular ROS level is undertight control by various antioxidants. Any disruption in the oxidation–antioxidation balance will lead to oxidative stress which is associated with a wide spectrum of human disorders. SkQ1 is a new antioxidant with the highest mitochondrion membrane penetrating ability and potent antioxidant capability. SkQ1 up-regulated production of angiogenic factors in serum and tumor of PDAC (pancreatic ductal adenocarcinoma)-bearing mice. Furthermore, an increase was observed in VEGF (vascular endothelial growth factor) concentration in serum of mice treated with SkQ1. Also, an increase in the IL-6 and IL-13 amount was found in the SkQ1 treated groups and the TGF-β amount was decreased in the pretreatment setting supporting the fact that SkQ1 can directly influence cytokine production from immune cells. This can be further illustrated by a significant decrease in the TNF-α and IFN-α production and a tendency to decrease the production of IL-6 and IL-10. Moreover, this drug at 500 nM concentration reduced heavily the proliferation of human PDAC cells[1].

Visomitin 参考文献

[1]Bazhin AV, Yang Y, D'Haese JG, Werner J, Philippov PP, Karakhanova S. The novel mitochondria-targeted antioxidant SkQ1 modulates angiogenesis and inflammatory micromilieu in a murine orthotopic model of pancreatic cancer. Int J Cancer. 2016;139(1):130-139

Visomitin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.62mL

0.32mL

0.16mL

8.10mL

1.62mL

0.81mL

16.19mL

3.24mL

1.62mL

Visomitin 技术信息

CAS号934826-68-3
分子式C36H42BrO2P
分子量 617.6
SMILES Code O=C(C(CCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=C4)C(C)=C(C)C4=O.[Br-]
MDL No. MFCD29477502
别名 SKQ1; SKQ1 (bromide)
运输蓝冰
InChI Key WYHFWTRUGAFNKW-UHFFFAOYSA-M
Pubchem ID 16679091
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, store in freezer, under -20°C

溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
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