VU 0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.
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VU0152100 (VU152100) is a highly selective mAChR positive allosteric modulator that crosses the blood-brain barrier. It counteracts Amphetamine-induced hypermotility in rats and elevates extracellular dopamine levels in the nucleus accumbens and caudate-putamen. VU0152100 shows significant research potential for treating psychosis and cognitive impairment related to mental disorders like schizophrenia[1][2].
VU0152100 动物研究
Animal study
VU0152100 (10, 30, 56.6 mg/kg; i.p.; single) counters amphetamine-induced hyperlocomotion in rats[1].VU0152100 (10, 30, 56.6 mg/kg; i.p.; single) inhibits amphetamine-induced disruption of contextual fear conditioning acquisition and prepulse inhibition of the acoustic startle reflex in rats[1].VU0152100 counteracts amphetamine-induced elevations in extracellular dopamine levels in the nucleus accumbens and caudate-putamen[1].
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